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ABSTRACT Introduction Competitive aerobics is a high-level sport that has the achievement of the championship and the pursuit of excellence as its primary objective. Strengthening the core is an integral part of sports training. Personalized core strength training for athletes in aerobics gymnastics is critical for sports success. Objective To study the core strength training of university aerobics gymnastics athletes exploring its effects on physical conditioning and skills. Methods After the literature survey, mathematical statistics discuss core strength training methods focused on female aerobics college athletes. Results Women's aerobics athletes' static squats, full squats with weights, and load intensity directly interfere with the difficulty and performance of aerobic movements. This experiment's organizing hip supine, push-up, and abdominal control are very significant. Conclusion Core strength training helps improve the physical conditioning of female college aerobics athletes. Evidence Level II; Therapeutic Studies - Investigating the results.
RESUMO Introdução A aeróbica competitiva é um esporte de alto nível que tem como objetivo principal a superação do campeonato e a busca da excelência. O fortalecimento do core é parte importante do treino esportivo. Um treino de força do core personalizado para atletas em aeróbica é fundamental para o êxito esportivo. Objetivo Estudar o treino de fortalecimento no core das atletas universitárias de ginástica aeróbica explorando seus efeitos sobre o condicionamento físico e habilidades. Métodos Após o levantamento bibliográfico, utiliza-se de estatísticas matemáticas para discutir os métodos de treino de força do core focado em atletas universitárias de aeróbica. Resultados Os agachamentos estáticos das atletas de aeróbica feminina, agachamentos completos com pesos e intensidade de carga interferem diretamente no nível de dificuldade e desempenho dos movimentos aeróbicos. Nesse experimento, organizar o apoio supino do quadril, flexão de braço, e controle abdominal são muito significativos. Conclusão O treino da força do core ajuda a melhorar o condicionamento físico das atletas universitárias de aeróbica. Nível de evidência II; Estudos Terapêuticos - Investigação de Resultados.
RESUMEN Introducción El aerobismo competitivo es un deporte de alto nivel que tiene como principal objetivo la superación del campeonato y la búsqueda de la excelencia. El fortalecimiento del core es una parte importante del entrenamiento deportivo. Un entrenamiento de fuerza del core personalizado para atletas en aerobismo es de fundamental importancia para el éxito deportivo. Objetivo Estudiar el entrenamiento del core de las atletas universitarias de gimnastica aeróbica explorando sus efectos en la condición física y las habilidades. Métodos Tras el estudio de la literatura, se utiliza la estadística matemática para discutir los métodos de entrenamiento del core centrados en las atletas universitarias de aerobismo. Resultados Las sentadillas estáticas de las atletas de aerobismo, las sentadillas completas con pesas y la intensidad de la carga interfieren directamente en el nivel de dificultad y el rendimiento de los movimientos aeróbicos. En este experimento, para organizar el apoyo de la cadera en posición supina, la flexión del brazo y el control abdominal son muy significativos. Conclusión El entrenamiento del core ayuda a mejorar la condición física de las atletas de aerobismo universitario. Nivel de evidencia II; Estudios terapéuticos - Investigación de resultados.
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Objective:This study aims to explore the anticancer effects and potential mechanisms of HJC0152, a novel STAT3 inhibitor, on the invasion and migration capacities of human head and neck squamous cell carcinoma (HNSCC) cell lines in vitro. Methods:Cells were divided into two groups, the dimethyl sulfoxide (DMSO) group and the HJC0152 group in which HNSCC cell lines UM-1 and SCC-15 were treated with DMSO or HJC0152 for 24 h. The total expression levels of STAT3, p-STAT3 (Tyr705/Ser727), MMP-2/9, N/E-cadherin, TWIST1, and vimentin;and the cytoplasm and nuclear expression levels of STAT3 and p-STAT3 (Tyr705/Ser727) were detected by Western blot assay. Wound healing and Transwell assays were employed to detect the invasion and migration abilities of the UM-1 and SCC-15 cells. The expression and location of N/E-cadherin were visualized by immunofluorescence staining. Results:Western blot indicated that the total expression of p-STAT3 (Tyr705), MMP-2/9, N-cadherin, TWIST1, and vimentin were significantly declined and that E-cadherin was remarkably elevated in the HJC0152 group cells compared with that of the DMSO group, with no difference in STAT3 or p-STAT3 (Ser727). Cytoplasm and nuclear STAT3 (Tyr705) were also inhibited by HJC0152. Wound healing and Transwel assays indicated that tumor invasion and migration capacities were impressively attenuated in the HJC0152 group cells compared to that of the DMSO group. Conclusion:HJC0152 suppresses the phosphorylation of STAT3 at Tyr705 in the HNSCC cell lines, leading to impair transcription activity, deplete expression levels of target genes, and subsequently inhibit migration and invasion capabilities of HNSCC.
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Objective:This study aims to explore the anticancer effects and potential mechanisms of HJC0152, a novel STAT3 inhibitor, on the invasion and migration capacities of human head and neck squamous cell carcinoma (HNSCC) cell lines in vitro. Methods:Cells were divided into two groups, the dimethyl sulfoxide (DMSO) group and the HJC0152 group in which HNSCC cell lines UM-1 and SCC-15 were treated with DMSO or HJC0152 for 24 h. The total expression levels of STAT3, p-STAT3 (Tyr705/Ser727), MMP-2/9, N/E-cadherin, TWIST1, and vimentin;and the cytoplasm and nuclear expression levels of STAT3 and p-STAT3 (Tyr705/Ser727) were detected by Western blot assay. Wound healing and Transwell assays were employed to detect the invasion and migration abilities of the UM-1 and SCC-15 cells. The expression and location of N/E-cadherin were visualized by immunofluorescence staining. Results:Western blot indicated that the total expression of p-STAT3 (Tyr705), MMP-2/9, N-cadherin, TWIST1, and vimentin were significantly declined and that E-cadherin was remarkably elevated in the HJC0152 group cells compared with that of the DMSO group, with no difference in STAT3 or p-STAT3 (Ser727). Cytoplasm and nuclear STAT3 (Tyr705) were also inhibited by HJC0152. Wound healing and Transwel assays indicated that tumor invasion and migration capacities were impressively attenuated in the HJC0152 group cells compared to that of the DMSO group. Conclusion:HJC0152 suppresses the phosphorylation of STAT3 at Tyr705 in the HNSCC cell lines, leading to impair transcription activity, deplete expression levels of target genes, and subsequently inhibit migration and invasion capabilities of HNSCC.